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| カタログ番号 | HV209014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-LAMTOR3 Polyclonal Antibody (HV209014) is a rabbit polyclonal antibody detecting LAMTOR3 in ELISA, IHC, WB. Suitable for Bovine, Danio rerio, Chicken, Human, and Mouse.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LAMTOR3 (Met1-Ser124). | ||||||||
| ターゲット | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, Mitogen-activated protein kinase kinase 1-interacting protein 1, Ragulator complex protein LAMTOR3, LAMTOR3, MAP2K1IP1, MAPKSP1, MEK-binding partner 1, Mitogen-activated protein kinase scaffold protein 1, Mp1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UHA4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ragulator complex protein LAMTOR3 is a ~13 kDa protein. As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. 1. Sancak, Y. et al. (2010) Cell 141, 290-303. PMID: 20381137 2. Bar-Peled, L. et al. (2012) Cell 150, 1196-208. PMID: 22980980 3. de Araujo, MEG. et al. (2017) Science (New York, N.Y.) 358, 377-381. PMID: 28935770 4. Su, MY. et al. (2017) Molecular cell 68, 835-846.e3. PMID: 29107538 5. Zhang, T. et al. (2017) Nature communications 8, 1394. PMID: 29123114 6. Yonehara, R. et al. (2017) Nature communications 8, 1625. PMID: 29158492 7. Shen, K. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 9545-9550. PMID: 30181260 | ||||||||
| 注意事項 | For research use only. |
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