Anti-Human LAMTOR3/MAP2K1IP1 Recombinant Antibody (SAA1946) (HV209013)

Name: Anti-Human LAMTOR3/MAP2K1IP1 Recombinant Antibody (SAA1946)
Brand: abinScience
SKU: HV209013
Price: 196 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV209013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1946

Clonality

Monoclonal

Target

Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, Mitogen-activated protein kinase kinase 1-interacting protein 1, Ragulator complex protein LAMTOR3, LAMTOR3, MAP2K1IP1, MAPKSP1, MEK-binding partner 1, Mitogen-activated protein kinase scaffold protein 1, Mp1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9UHA4

RRID

Anti-Human LAMTOR3/MAP2K1IP1 Antibody (SAA1946) (abinScience Cat# HV209013, RRID:AB_3727710)
_x005f_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Ragulator complex protein LAMTOR3 is a ~13 kDa protein. As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

1. Sancak, Y. et al. (2010) Cell 141, 290-303. PMID: 20381137

2. Bar-Peled, L. et al. (2012) Cell 150, 1196-208. PMID: 22980980

3. de Araujo, MEG. et al. (2017) Science (New York, N.Y.) 358, 377-381. PMID: 28935770

4. Su, MY. et al. (2017) Molecular cell 68, 835-846.e3. PMID: 29107538

5. Zhang, T. et al. (2017) Nature communications 8, 1394. PMID: 29123114

6. Yonehara, R. et al. (2017) Nature communications 8, 1625. PMID: 29158492

7. Shen, K. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 9545-9550. PMID: 30181260

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human LAMTOR3/MAP2K1IP1 Antibody (SAA1946)

References

Datasheet

Anti-Human LAMTOR3/MAP2K1IP1 Recombinant Antibody (SAA1946).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human LAMTOR3/MAP2K1IP1 Recombinant Antibody (SAA1946) (HV209013)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us