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| カタログ番号 | HV606014 | ||||||||
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| 説明 |
Anti-LGMN Polyclonal Antibody (HV606014) is a rabbit polyclonal antibody detecting LGMN in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, and Pongo abelii.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LGMN (Pro19-His432). | ||||||||
| ターゲット | PRSC1, Legumain, Asparaginyl endopeptidase, LGMN, Protease, cysteine 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99538 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Legumain (LGMN) is a ~49 kDa protein. Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. 1. Dall, E. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10940-5. PMID: 23776206 2. Manoury, B. et al. (1998) Nature 396, 695-9. PMID: 9872320 | ||||||||
| 注意事項 | For research use only. |
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