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Anti-Mouse ANG Polyclonal Antibody (MY052014)

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Vista general
Número de catálogoMY052014
Descripción
Anti-Mouse ANG Polyclonal Antibody (MY052014) is a rabbit polyclonal antibody detecting Angiogenin; 3.1.27.-; Angiogenin-1; Ribonuclease 5; RNase 5; Ang; Ang1; Rnase5; Rnase5a in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesMouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant mouse ANG (Gln25-Leu145).
Objetivo Angiogenin; 3.1.27.-; Angiogenin-1; Ribonuclease 5; RNase 5; Ang; Ang1; Rnase5; Rnase5a
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P21570
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Angiogenin is a ~16 kDa protein. Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context. Endocytosed in target cells via its receptor PLXNB2 and translocates to the cytoplasm or nucleus. Under stress conditions, localizes to the cytoplasm and promotes the assembly of stress granules (SGs): specifically cleaves a subset of tRNAs within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs), resulting in translation repression and inhibition of cell proliferation. tiRNas also prevent formation of apoptosome, thereby promoting cell survival. Preferentially cleaves RNAs between a pyrimidine and an adenosine residue, suggesting that it cleaves the anticodon loop of tRNA(Ala) (32-UUAGCAU-38) after positions 33 and 36.

1. Fu, H. et al. (2009) FEBS letters 583, 437-42. PMID: 19114040
2. Goncalves, KA. et al. (2016) Cell 166, 894-906. PMID: 27518564
3. Bai, R. et al. (2020) The EMBO journal 39, e103325. PMID: 32510170
4. Liu, X. et al. (2021) Nature communications 12, 1832. PMID: 33758201
5. Yue, T. et al. (2021) Science (New York, N.Y.) 372. PMID: 33986151
6. Yu, W. et al. (2017) Cell 171, 849-864.e25. PMID: 29100074
7. Saikia, M. et al. (2014) Molecular and cellular biology 34, 2450-63. PMID: 24752898
Nota For research use only
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Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Mouse ANG Polyclonal Antibody

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