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| カタログ番号 | MC275014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse CD150/SLAMF1 Polyclonal Antibody (MC275014) is a rabbit polyclonal antibody detecting SLAMF1. Suitable for Mouse.
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CD150/SLAMF1 (Asp31-Cys232). | ||||||||
| ターゲット | CD150, CDw150, IPO-3, SLAM, SLAM family member 1, SLAMF1, Signaling lymphocytic activation molecule | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9QUM4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Signaling lymphocytic activation molecule (CD150/SLAMF1) is a ~38 kDa protein. Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. 1. Howie, D. et al. (2002) Blood 100, 2899-907. PMID: 12351401 2. Aversa, G. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 4036-44. PMID: 9126961 3. Latour, S. et al. (2001) Nature immunology 2, 681-90. PMID: 11477403 4. Cannons, JL. et al. (2004) Immunity 21, 693-706. PMID: 15539155 5. Chen, R. et al. (2006) Molecular and cellular biology 26, 5559-68. PMID: 16847311 6. Wang, N. et al. (2004) The Journal of experimental medicine 199, 1255-64. PMID: 15123745 7. Yusuf, I. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 190-202. PMID: 20525889 8. Wang, N. et al. (2006) American journal of respiratory cell and molecular biology 35, 206-10. PMID: 16528012 9. Griewank, K. et al. (2007) Immunity 27, 751-62. PMID: 18031695 | ||||||||
| 注意事項 | For research use only |
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