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| カタログ番号 | MX200107 |
|---|---|
| 種反応性 | Human, Mouse |
| アプリケーション | ELISA, FCM |
| 宿主種 | Rat |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | A12 |
| ターゲット | Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, Adam17, Tace |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q9Z0F8 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Disintegrin and metalloproteinase domain-containing protein 17 (CD156b/ADAM17) is a ~93 kDa protein. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT). 1. Reddy, P. et al. (2000) The Journal of biological chemistry 275, 14608-14. PMID: 10799547 2. Zhang, Y. et al. (2000) Endocrinology 141, 4342-8. PMID: 11108241 3. Brou, C. et al. (2000) Molecular cell 5, 207-16. PMID: 10882063 4. Bergmeier, W. et al. (2003) Blood 102, 4229-35. PMID: 12907434 5. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Mouse CD156b/ADAM17 Antibody (A12)
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