Anti-Mouse CD156b/ADAM17 Recombinant Antibody (A12), APC (MX200137)

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Catalog No.	MX200137
Description	Anti-Mouse CD156b/ADAM17 Antibody (A12), APC [A12] (MX200137) is a rat monoclonal antibody detecting CD156b in ELISA, FCM. Suitable for Human and Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human, Mouse
Applications	ELISA, FCM
Host species	Rat
Isotype	IgG1, kappa
Clone ID	A12
Conjugation	APC
Clonality	Monoclonal
Target	Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, Adam17, Tace
Endotoxin level	Please contact with the lab for this information.
Accession	Q9Z0F8
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Disintegrin and metalloproteinase domain-containing protein 17 (CD156b/ADAM17) is a ~93 kDa protein. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT). 1. Reddy, P. et al. (2000) The Journal of biological chemistry 275, 14608-14. PMID: 10799547 2. Zhang, Y. et al. (2000) Endocrinology 141, 4342-8. PMID: 11108241 3. Brou, C. et al. (2000) Molecular cell 5, 207-16. PMID: 10882063 4. Bergmeier, W. et al. (2003) Blood 102, 4229-35. PMID: 12907434 5. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse CD156b/ADAM17 Recombinant Antibody (A12), APC.pdf

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Anti-Mouse CD156b/ADAM17 Recombinant Antibody (A12), APC (MX200137)

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