Anti-Mouse CD156b/ADAM17 Recombinant Antibody (A12) (MX200107)

Name: Anti-Mouse CD156b/ADAM17 Recombinant Antibody (A12)
Brand: abinScience
SKU: MX200107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	MX200107
Species reactivity	Human, Mouse
Applications	ELISA, FCM
Host species	Rat
Isotype	IgG1, kappa
Clone ID	A12
Clonality	Monoclonal
Target	Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, Adam17, Tace
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9Z0F8
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Disintegrin and metalloproteinase domain-containing protein 17 (CD156b/ADAM17) is a ~93 kDa protein. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT). 1. Reddy, P. et al. (2000) The Journal of biological chemistry 275, 14608-14. PMID: 10799547 2. Zhang, Y. et al. (2000) Endocrinology 141, 4342-8. PMID: 11108241 3. Brou, C. et al. (2000) Molecular cell 5, 207-16. PMID: 10882063 4. Bergmeier, W. et al. (2003) Blood 102, 4229-35. PMID: 12907434 5. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433
Note	For research use only.

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SDS-PAGE for Anti-Mouse CD156b/ADAM17 Antibody (A12)

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Datasheet

Anti-Mouse CD156b/ADAM17 Recombinant Antibody (A12).pdf

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Anti-Mouse CD156b/ADAM17 Recombinant Antibody (A12) (MX200107)

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