Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7) (MT182107)

Name: Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7)
Brand: abinScience
SKU: MT182107
Price: 191 USD
Availability: InStock

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Vista general

Número de catálogo	MT182107
Marca	abinScience
Reactividad de especies	Human, Mouse, Bovine
Aplicaciones	FCM, IF, IHC, IP
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	8C7
Objetivo	ADAM 10, Mammalian disintegrin-metalloprotease, CD156c, MADM, ADAM10, Kuzbanian protein homolog, KUZ, CDw156, Disintegrin and metalloproteinase domain-containing protein 10
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	O35598
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Disintegrin and metalloproteinase domain-containing protein 10 (CD156c/ADAM10) is a ~83 kDa protein. Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-\|-Leu-688'. 1. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433 2. Wang, X. et al. (2018) Journal of molecular cell biology 10, 411-422. PMID: 29325091 3. Brummer, T. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 3560-3573. PMID: 29430990 4. Defourny, J. et al. (2019) iScience 11, 246-257. PMID: 30639848 5. Noy, PJ. et al. (2016) The Journal of biological chemistry 291, 3145-57. PMID: 26668317 6. Shah, J. et al. (2018) Cell reports 25, 2132-2147.e7. PMID: 30463011 7. Pan, D. et al. (1997) Cell 90, 271-80. PMID: 9244301 8. Hammad, H. et al. (2017) Nature immunology 18, 313-320. PMID: 28068307
Nota	For research use only.

Imágenes

Bioactivity

SEC-HPLC detection for Anti-Mouse CD156c/ADAM10 Antibody (8C7).
SDS-PAGE

SDS-PAGE for Anti-Mouse CD156c/ADAM10 Antibody (8C7)

Referencias

Datasheet

Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7).pdf

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Formula

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