Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7), APC (MT182137)

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Catalog No.	MT182137
Description	Anti-Mouse CD156c/ADAM10 Antibody (8C7), APC [8C7] (MT182137) is a mouse monoclonal antibody detecting CD156c in FCM, IF. Suitable for Human, Mouse, and Bovine. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows. ●Multi-Species — Cross-reactive for translational research.
Species reactivity	Human, Mouse, Bovine
Applications	FCM, IF
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	8C7
Conjugation	APC
Clonality	Monoclonal
Target	ADAM 10, Mammalian disintegrin-metalloprotease, CD156c, MADM, ADAM10, Kuzbanian protein homolog, KUZ, CDw156, Disintegrin and metalloproteinase domain-containing protein 10
Endotoxin level	Please contact with the lab for this information.
Accession	O35598
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Disintegrin and metalloproteinase domain-containing protein 10 (CD156c/ADAM10) is a ~83 kDa protein. Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-\|-Leu-688'. 1. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433 2. Wang, X. et al. (2018) Journal of molecular cell biology 10, 411-422. PMID: 29325091 3. Brummer, T. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 3560-3573. PMID: 29430990 4. Defourny, J. et al. (2019) iScience 11, 246-257. PMID: 30639848 5. Noy, PJ. et al. (2016) The Journal of biological chemistry 291, 3145-57. PMID: 26668317 6. Shah, J. et al. (2018) Cell reports 25, 2132-2147.e7. PMID: 30463011 7. Pan, D. et al. (1997) Cell 90, 271-80. PMID: 9244301 8. Hammad, H. et al. (2017) Nature immunology 18, 313-320. PMID: 28068307
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7), APC.pdf

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Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7), APC (MT182137)

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