Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7) (MT182107)

Name: Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7)
Brand: abinScience
SKU: MT182107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	MT182107
Species reactivity	Bovine
Applications	FCM, IF, IHC, IP
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	8C7
Clonality	Monoclonal
Target	ADAM 10, Mammalian disintegrin-metalloprotease, CD156c, MADM, ADAM10, Kuzbanian protein homolog, KUZ, CDw156, Disintegrin and metalloproteinase domain-containing protein 10
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O35598
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Disintegrin and metalloproteinase domain-containing protein 10 (CD156c/ADAM10) is a ~83 kDa protein. Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-\|-Leu-688'. 1. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433 2. Wang, X. et al. (2018) Journal of molecular cell biology 10, 411-422. PMID: 29325091 3. Brummer, T. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 3560-3573. PMID: 29430990 4. Defourny, J. et al. (2019) iScience 11, 246-257. PMID: 30639848 5. Noy, PJ. et al. (2016) The Journal of biological chemistry 291, 3145-57. PMID: 26668317 6. Shah, J. et al. (2018) Cell reports 25, 2132-2147.e7. PMID: 30463011 7. Pan, D. et al. (1997) Cell 90, 271-80. PMID: 9244301 8. Hammad, H. et al. (2017) Nature immunology 18, 313-320. PMID: 28068307
Note	For research use only.

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Bioactivity

SEC-HPLC detection for Anti-Mouse CD156c/ADAM10 Antibody (8C7).
SDS-PAGE

SDS-PAGE for Anti-Mouse CD156c/ADAM10 Antibody (8C7)

References

Datasheet

Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7).pdf

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Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7) (MT182107)

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