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| カタログ番号 | MT182107 |
|---|---|
| ブランド | abinScience |
| 種反応性 | Human, Mouse, Bovine |
| アプリケーション | FCM, IF, IHC, IP |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | 8C7 |
| ターゲット | ADAM 10, Mammalian disintegrin-metalloprotease, CD156c, MADM, ADAM10, Kuzbanian protein homolog, KUZ, CDw156, Disintegrin and metalloproteinase domain-containing protein 10 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | O35598 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Disintegrin and metalloproteinase domain-containing protein 10 (CD156c/ADAM10) is a ~83 kDa protein. Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-|-Leu-688'. 1. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433 2. Wang, X. et al. (2018) Journal of molecular cell biology 10, 411-422. PMID: 29325091 3. Brummer, T. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 3560-3573. PMID: 29430990 4. Defourny, J. et al. (2019) iScience 11, 246-257. PMID: 30639848 5. Noy, PJ. et al. (2016) The Journal of biological chemistry 291, 3145-57. PMID: 26668317 6. Shah, J. et al. (2018) Cell reports 25, 2132-2147.e7. PMID: 30463011 7. Pan, D. et al. (1997) Cell 90, 271-80. PMID: 9244301 8. Hammad, H. et al. (2017) Nature immunology 18, 313-320. PMID: 28068307 |
| 注意事項 | For research use only. |
SEC-HPLC detection for Anti-Mouse CD156c/ADAM10 Antibody (8C7).
SDS-PAGE for Anti-Mouse CD156c/ADAM10 Antibody (8C7)
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