Anti-Mouse SIRP alpha/CD172a Recombinant Antibody (SAA0817), PE (MX892127)

Name: Anti-Mouse SIRP alpha/CD172a Recombinant Antibody (SAA0817), PE
Brand: abinScience
SKU: MX892127
Price: 290 USD
Availability: InStock

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Número de catálogo	MX892127
Reactividad de especies	Mouse
Aplicaciones	ELISA, FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1
ID de clon	SAA0817
Conjugación	PE
Objetivo	BIT, Bit, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a, Inhibitory receptor SHPS-1, MFR, MYD1, Macrophage fusion receptor, MyD-1 antigen, PTPNS1, SHP substrate 1, SHPS-1, SHPS1, SIRP, SIRPA, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, p84
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Productos asociados	Mouse IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PE
Número de acceso	P97797
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~56 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. 1. Nakaishi, A. et al. (2008) Journal of molecular biology 375, 650-60. PMID: 18045614 2. Sarute, N. et al. (2019) PLoS biology 17, e3000137. PMID: 30726215
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Mouse SIRP alpha/CD172a Recombinant Antibody (SAA0817), PE.pdf

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