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| カタログ番号 | MB996127 |
|---|---|
| 種反応性 | Mouse |
| アプリケーション | FCM |
| 宿主種 | Rat |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2a, kappa |
| クローンID | 1D3 |
| 抱合 | PE |
| ターゲット | B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 関連製品 | Rat IgG2a, kappa Recombinant Isotype Control Antibody (RTK2758), PE |
| アクセッション番号 | P25918 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | B-lymphocyte antigen CD19 is a ~60 kDa protein. Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. CD19 is the therapeutic target of tafasitamab (Monjuvi). 1. Wang, Y. et al. (2002) Immunity 17, 501-14. PMID: 12387743 2. Ishiura, N. et al. (2010) European journal of immunology 40, 1192-204. PMID: 20101619 3. Buhl, AM. et al. (1997) The Journal of experimental medicine 186, 1897-910. PMID: 9382888 4. Engel, P. et al. (1995) Immunity 3, 39-50. PMID: 7542548 5. Rickert, RC. et al. (1995) Nature 376, 352-5. PMID: 7543183 6. Sato, S. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 3278-87. PMID: 9317126 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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