Anti-Mouse CCR8 Recombinant Antibody (SAA2201) (MW444107)

Name: Anti-Mouse CCR8 Recombinant Antibody (SAA2201)
Brand: abinScience
SKU: MW444107
Price: 196 USD
Availability: InStock

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Número de catálogo	MW444107
Reactividad de especies	Mouse
Aplicaciones	ELISA, FCM, Neutralization
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, lambda
ID de clon	SAA2201
Objetivo	C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CDw198, Ccr8, Cmkbr8, Ter1
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P56484
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production. 1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461 2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588 3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532
Nota	For research use only.