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Anti-Mouse CD21/CD35 Recombinant Antibody (7G6), APC (MB939137)

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Vista general
Número de catálogoMB939137
Reactividad de especiesMouse
AplicacionesELISA, FCM, WB
Especie huéspedMouse
ClonalidadMonoclonal
IsotipoIgG2a, kappa
ID de clon7G6
ConjugaciónAPC
Objetivo CR1, CD35, Complement receptor type 1, CR1/CR2, C3DR, CD21, CD21/CD35, Cr-1, Cr-2
Nivel de endotoxinas Please contact with the lab for this information.
Productos asociados Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
Número de acceso P19070
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Estabilidad y almacenamiento Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo

Complement receptor type 2 (CD21/CD35) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner.

Nota For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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