

| Número de catálogo | MB939107 |
|---|---|
| Reactividad de especies | Mouse |
| Aplicaciones | ELISA, FCM, IHC, IP, WB |
| Especie huésped | Mouse |
| Clonalidad | Monoclonal |
| Isotipo | IgG2a, kappa |
| ID de clon | 7G6 |
| Objetivo | CR1, CD35, Complement receptor type 1, CR1/CR2, C3DR, CD21, CD21/CD35, Cr-1, Cr-2 |
| Nivel de endotoxinas | Please contact with the lab for this information. |
| Pureza | >95% as determined by SDS-PAGE. |
| Purificación | Protein A/G purified from cell culture supernatant. |
| Número de acceso | P19070 |
| Forma | Liquid |
| Buffer de almacenamiento | 0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Fondo | Complement receptor type 2 (CD21/CD35) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. |
| Nota | For research use only. |

SDS-PAGE for Anti-Mouse CD21/CD35 Antibody (7G6)




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