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Anti-Mouse CD21/CR2 Polyclonal Antibody (MB939014)

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Vista general
Número de catálogoMB939014
Descripción
Anti-Mouse CD21/CR2 Polyclonal Antibody (MB939014) is a rabbit polyclonal antibody detecting CD21. Suitable for Mouse.
Reactividad de especiesMouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Mouse CD21/CR2 (Ile12-Ala205).
Objetivo C3DR, CD21, CR2, Complement C3d receptor, Complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P19070
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Complement receptor type 2 (CD21/CR2) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner.

Nota For research use only
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