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| カタログ番号 | MV681137 |
|---|---|
| 種反応性 | Human, Mouse |
| アプリケーション | ELISA, FCM |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, lambda |
| クローンID | G78 |
| 抱合 | APC |
| ターゲット | Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Human IgG1, lambda Isotype Control antibody (HyHEL-10), APC |
| アクセッション番号 | Q91V98 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Endosialin (CD248) is a ~81 kDa protein. Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory responses in macrophages by favoring production of proinflammatory cytokines. 1. Opavsky, R. et al. (2001) The Journal of biological chemistry 276, 38795-807. PMID: 11489895 2. Naylor, AJ. et al. (2014) PloS one 9, e107146. PMID: 25243742 3. Benedet, PO. et al. (2024) EBioMedicine 99, 104906. PMID: 38061240 4. Hong, YK. et al. (2019) The Journal of investigative dermatology 139, 2204-2214.e7. PMID: 30986375 5. Kapopara, PR. et al. (2021) Journal of thrombosis and haemostasis : JTH 19, 1932-1947. PMID: 33830628 6. Cheng, TL. et al. (2021) Translational research : the journal of laboratory and clinical medicine 232, 150-162. PMID: 33737161 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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