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| カタログ番号 | MV974107 |
|---|---|
| 種反応性 | Mouse |
| アプリケーション | ELISA, FCM |
| 宿主種 | Rat |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | SAA0268 |
| ターゲット | B7 homolog 1, B7-H1, B7H1, CD274, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1 |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q9EP73 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Programmed cell death 1 ligand 1 (CD274/PD-L1) is a ~32 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). CD274 is the therapeutic target of atezolizumab (Tecentriq) and durvalumab (Imfinzi). 1. Tamura, H. et al. (2001) Blood 97, 1809-16. PMID: 11238124 2. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443 3. Wang, S. et al. (2003) The Journal of experimental medicine 197, 1083-91. PMID: 12719480 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Mouse CD274/PD-L1/B7-H1 Antibody (SAA0268)
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