

| Каталожный номер | MT188137 |
|---|---|
| Реактивность видов | Mouse |
| Применения | FCM, IF, WB |
| Хозяинский вид | Mouse |
| Клоональность | Monoclonal |
| Изотип | IgG2a, kappa |
| ID клона | SAA1384 |
| Конъюгация | APC |
| Цель | TIL4, Toll-like receptor 2, TLR2, Toll/interleukin-1 receptor-like protein 4, CD282 |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Связанные продукты | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC |
| Номер доступа | Q9QUN7 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Фон | Toll-like receptor 2 (CD282/TLR2) is a ~89 kDa protein. Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. 1. Hoebe, K. et al. (2005) Nature 433, 523-7. PMID: 15690042 2. Pathak, SK. et al. (2007) Nature immunology 8, 610-8. PMID: 17486091 3. Drage, MG. et al. (2009) Cellular immunology 258, 29-37. PMID: 19362712 4. Chen, ST. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 668-77. PMID: 22174456 5. Deboosère, N. et al. (2017) Cellular microbiology 19. PMID: 27220037 |
| Примечание | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |




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