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Anti-Mouse Neuropilin-1/NRP1 Recombinant Antibody (YW64.3), PE (MT070227)

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Aperçu
Numéro de catalogueMT070227
Reactivité des espècesHuman, Mouse
ApplicationsELISA, FCM
Espèce hôteRat
ClonalitéMonoclonal
IsotypeIgG1, kappa
ID de cloneYW64.3
ConjugaisonPE
Cible NRP1, Neuropilin-1, VEGF165R, NRP, CD304, Vascular endothelial cell growth factor 165 receptor
Niveau d'endotoxines Please contact with the lab for this information.
Produits associés Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PE
Numéro d'accès P97333
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Stabilité et stockage Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte

Neuropilin-1 (CD304/NRP1) is a ~103 kDa protein. Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis.

1. He, W. et al. (2015) Nature 526, 710-4. PMID: 26503042
Note For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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