

| Numéro de catalogue | MT070117 |
|---|---|
| Reactivité des espèces | Human, Mouse |
| Applications | ELISA, FCM |
| Espèce hôte | Rat |
| Clonalité | Monoclonal |
| Isotype | IgG1, kappa |
| ID de clone | YW68.11.26 |
| Conjugaison | FITC |
| Cible | NRP1, Neuropilin-1, VEGF165R, NRP, CD304, Vascular endothelial cell growth factor 165 receptor, Vascular endothelial cell growth factor 165 receptor 2, Neuropilin-2, VEGF165R2, NRP2 |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Produits associés | Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), FITC |
| Numéro d'accès | P97333, O35375 |
| Forme | Liquid |
| Tampon de stockage | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Stabilité et stockage | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Contexte | Neuropilin-1 (NRP1/NRP2) is a ~103 kDa protein. Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. 1. He, W. et al. (2015) Nature 526, 710-4. PMID: 26503042 |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |




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