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Anti-Mouse CD304/NRP1/NRP2 Recombinant Antibody (YW68.11.26), PerCP (MT070147)

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Overview
Catalog No.MT070147
Species reactivityHuman, Mouse
ApplicationsELISA, FCM
Host speciesRat
IsotypeIgG1, kappa
Clone IDYW68.11.26
ConjugationPerCP
Clonality Monoclonal
Target NRP1, Neuropilin-1, VEGF165R, NRP, CD304, Vascular endothelial cell growth factor 165 receptor, Vascular endothelial cell growth factor 165 receptor 2, Neuropilin-2, VEGF165R2, NRP2
Endotoxin level Please contact with the lab for this information.
Associated products Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PerCP
Accession P97333, O35375
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Store at 4°C for 12 months. Protect from light. Do not freeze.
Background

Neuropilin-1 (NRP1/NRP2) is a ~103 kDa protein. Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis.

1. He, W. et al. (2015) Nature 526, 710-4. PMID: 26503042
Note For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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