Anti-Mouse CD5L Polyclonal Antibody (MT064014)

Name: Anti-Mouse CD5L Polyclonal Antibody
Brand: abinScience
SKU: MT064014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

MT064014

Description

Anti-Mouse CD5L Polyclonal Antibody (MT064014) is a rabbit polyclonal antibody detecting Cd5l. Suitable for Mouse.

Reactivité des espèces

Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Mouse CD5L (Thr25-Val352).

Cible

Aim, Api6, Apoptosis inhibitor expressed by macrophages, Apoptosis inhibitory 6, CD5 antigen-like, Cd5l, SP-alpha, mAIM

Niveau d'endotoxines

Please contact with the lab for this information.

Masse moléculaire observée

40 kDa

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9QWK4

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Expédition

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

CD5 antigen-like (CD5L) is a ~38 kDa protein. Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC).

1. Sanjurjo, L. et al. (2015) Journal of leukocyte biology 98, 173-84. PMID: 26048980

2. Kurokawa, J. et al. (2010) Cell metabolism 11, 479-92. PMID: 20519120

3. Iwamura, Y. et al. (2012) Biochemical and biophysical research communications 422, 476-81. PMID: 22579686

4. Kurokawa, J. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 12072-7. PMID: 21730133

5. Wang, C. et al. (2015) Cell 163, 1413-27. PMID: 26607793

6. Gaublomme, JT. et al. (2015) Cell 163, 1400-12. PMID: 26607794

10. Arai, S. et al. (2016) Nature medicine 22, 183-93. PMID: 26726878

Note

For research use only

Images

Reférences

Fiche technique

Anti-Mouse CD5L Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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