Mouse CD5L Recombinant Protein (N-His) (MT064012)

Name: Mouse CD5L Recombinant Protein (N-His)
Brand: abinScience
SKU: MT064012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MT064012
Description	Recombinant Mouse CD5L Protein, N-His (MT064012) expressed in E. coli, spanning Thr25-Val352. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9QWK4
Protein length	Thr25-Val352
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	38.59 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	API6, Apoptosis inhibitor expressed by macrophages, CD5 antigen-like, CD5L, CT-2, IgM-associated peptide, SP-alpha, hAIM
Background	CD5 antigen-like is a ~38 kDa protein. Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). 1. Sanjurjo, L. et al. (2015) Journal of leukocyte biology 98, 173-84. PMID: 26048980 2. Kurokawa, J. et al. (2010) Cell metabolism 11, 479-92. PMID: 20519120 3. Iwamura, Y. et al. (2012) Biochemical and biophysical research communications 422, 476-81. PMID: 22579686 4. Kurokawa, J. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 12072-7. PMID: 21730133 5. Wang, C. et al. (2015) Cell 163, 1413-27. PMID: 26607793 6. Gaublomme, JT. et al. (2015) Cell 163, 1400-12. PMID: 26607794 10. Arai, S. et al. (2016) Nature medicine 22, 183-93. PMID: 26726878
Note	For research use only

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Mouse CD5L Recombinant Protein (N-His).pdf

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Mouse CD5L Recombinant Protein (N-His) (MT064012)

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