Anti-Mouse CD5L Polyclonal Antibody (MT064014)

Name: Anti-Mouse CD5L Polyclonal Antibody
Brand: abinScience
SKU: MT064014
Price: 168 USD
Availability: InStock

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SDS

Обзор

Каталожный номер

MT064014

Описание

Anti-Mouse CD5L Polyclonal Antibody (MT064014) is a rabbit polyclonal antibody detecting Cd5l. Suitable for Mouse.

Реактивность видов

Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Mouse CD5L (Thr25-Val352).

Цель

Aim, Api6, Apoptosis inhibitor expressed by macrophages, Apoptosis inhibitory 6, CD5 antigen-like, Cd5l, SP-alpha, mAIM

Уровень эндотоксинов

Please contact with the lab for this information.

Наблюдаемая молекулярная масса

40 kDa

Очистка

Purified by antigen affinity column.

Номер доступа

Q9QWK4

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Реконституция

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Доставка

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

CD5 antigen-like (CD5L) is a ~38 kDa protein. Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC).

1. Sanjurjo, L. et al. (2015) Journal of leukocyte biology 98, 173-84. PMID: 26048980

2. Kurokawa, J. et al. (2010) Cell metabolism 11, 479-92. PMID: 20519120

3. Iwamura, Y. et al. (2012) Biochemical and biophysical research communications 422, 476-81. PMID: 22579686

4. Kurokawa, J. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 12072-7. PMID: 21730133

5. Wang, C. et al. (2015) Cell 163, 1413-27. PMID: 26607793

6. Gaublomme, JT. et al. (2015) Cell 163, 1400-12. PMID: 26607794

10. Arai, S. et al. (2016) Nature medicine 22, 183-93. PMID: 26726878

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-Mouse CD5L Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа