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| カタログ番号 | MX855014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse CD81 Polyclonal Antibody (MX855014) is a rabbit polyclonal antibody detecting CD81 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CD81 (Phe113-Lys201). | ||||||||
| ターゲット | CD81 antigen, TSPAN28, Target of the antiproliferative antibody 1, Tspan-28, Tetraspanin-28, CD81, TAPA1, 26 kDa cell surface protein TAPA-1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P35762 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | CD81 antigen is a ~25 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells. Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response. In T cells, associates with CD4 or CD8 coreceptors and defines the maturation state of antigen-induced synapses with B cells. Facilitates localization of CD3 in these immune synapses, required for costimulation and sustained activation of T cells, preferentially triggering T helper type 2 immune response. 1. Mattila, PK. et al. (2013) Immunity 38, 461-74. PMID: 23499492 2. Deng, J. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 165, 5054-61. PMID: 11046035 3. Charrin, S. et al. (2013) Nature communications 4, 1674. PMID: 23575678 4. Rubinstein, E. et al. (2006) Developmental biology 290, 351-8. PMID: 16380109 5. Tanigawa, M. et al. (2008) Molecular reproduction and development 75, 150-5. PMID: 17290409 6. Takeda, Y. et al. (2008) The Journal of biological chemistry 283, 26089-97. PMID: 18662991 | ||||||||
| 注意事項 | For research use only. |
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