Mouse CD81 Recombinant Protein (C-Fc) (MX855011)

Name: Mouse CD81 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: MX855011
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	MX855011
Description	Recombinant Mouse CD81 Protein, C-Fc (MX855011) expressed in Mammalian Cells, spanning Phe113-Leu202. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	P35762
Protein length	Phe113-Leu202
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	38.14 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	26 kDa cell surface protein TAPA-1, CD81, CD81 antigen, TAPA1, TSPAN28, Target of the antiproliferative antibody 1, Tetraspanin-28, Tspan-28
Background	CD81 antigen is a ~25 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells. Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response. In T cells, associates with CD4 or CD8 coreceptors and defines the maturation state of antigen-induced synapses with B cells. Facilitates localization of CD3 in these immune synapses, required for costimulation and sustained activation of T cells, preferentially triggering T helper type 2 immune response. 1. Mattila, PK. et al. (2013) Immunity 38, 461-74. PMID: 23499492 2. Deng, J. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 165, 5054-61. PMID: 11046035 3. Charrin, S. et al. (2013) Nature communications 4, 1674. PMID: 23575678 4. Rubinstein, E. et al. (2006) Developmental biology 290, 351-8. PMID: 16380109 5. Tanigawa, M. et al. (2008) Molecular reproduction and development 75, 150-5. PMID: 17290409 6. Takeda, Y. et al. (2008) The Journal of biological chemistry 283, 26089-97. PMID: 18662991
Note	For research use only

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Datasheet

Mouse CD81 Recombinant Protein (C-Fc).pdf

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Mouse CD81 Recombinant Protein (C-Fc) (MX855011)

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