Anti-Mouse CD81 Polyclonal Antibody (MX855014)

Name: Anti-Mouse CD81 Polyclonal Antibody
Brand: abinScience
SKU: MX855014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
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Overview

Catalog No.

MX855014

Description

Anti-Mouse CD81 Polyclonal Antibody (MX855014) is a rabbit polyclonal antibody detecting CD81 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CD81 (Phe113-Lys201).

Target

CD81 antigen, TSPAN28, Target of the antiproliferative antibody 1, Tspan-28, Tetraspanin-28, CD81, TAPA1, 26 kDa cell surface protein TAPA-1

Purification

Purified by antigen affinity column.

Accession

P35762

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

CD81 antigen is a ~25 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells. Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response. In T cells, associates with CD4 or CD8 coreceptors and defines the maturation state of antigen-induced synapses with B cells. Facilitates localization of CD3 in these immune synapses, required for costimulation and sustained activation of T cells, preferentially triggering T helper type 2 immune response.

1. Mattila, PK. et al. (2013) Immunity 38, 461-74. PMID: 23499492

2. Deng, J. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 165, 5054-61. PMID: 11046035

3. Charrin, S. et al. (2013) Nature communications 4, 1674. PMID: 23575678

4. Rubinstein, E. et al. (2006) Developmental biology 290, 351-8. PMID: 16380109

5. Tanigawa, M. et al. (2008) Molecular reproduction and development 75, 150-5. PMID: 17290409

6. Takeda, Y. et al. (2008) The Journal of biological chemistry 283, 26089-97. PMID: 18662991

Note

For research use only.

Images

References

Datasheet

Anti-Mouse CD81 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse CD81 Polyclonal Antibody (MX855014)

Overview

Images

References

Datasheet

SDS

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