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| カタログ番号 | MV727014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse CIDEC Polyclonal Antibody (MV727014) is a rabbit polyclonal antibody detecting Cidec in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CIDEC (Arg41-Cys178). | ||||||||
| ターゲット | Lipid transferase CIDEC, Cell death-inducing DFFA-like effector protein C, Fat-specific protein FSP27, Cidec, Fsp27 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P56198 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Lipid transferase CIDEC is a ~27 kDa protein. Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. 1. Keller, P. et al. (2008) The Journal of biological chemistry 283, 14355-65. PMID: 18334488 2. Gong, J. et al. (2011) The Journal of cell biology 195, 953-63. PMID: 22144693 3. Xu, W. et al. (2016) The Journal of biological chemistry 291, 4282-93. PMID: 26733203 4. Wang, J. et al. (2018) The Journal of biological chemistry 293, 19330-19343. PMID: 30361435 5. Qian, K. et al. (2023) Nature 613, 160-168. PMID: 36477540 6. Toh, SY. et al. (2008) PloS one 3, e2890. PMID: 18682832 | ||||||||
| 注意事項 | For research use only. |
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