

| Каталожный номер | MV727014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse CIDEC Polyclonal Antibody (MV727014) is a rabbit polyclonal antibody detecting Cidec in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Реактивность видов | Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse CIDEC (Arg41-Cys178). | ||||||||
| Цель | Lipid transferase CIDEC, Cell death-inducing DFFA-like effector protein C, Fat-specific protein FSP27, Cidec, Fsp27 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P56198 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Lipid transferase CIDEC is a ~27 kDa protein. Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. 1. Keller, P. et al. (2008) The Journal of biological chemistry 283, 14355-65. PMID: 18334488 2. Gong, J. et al. (2011) The Journal of cell biology 195, 953-63. PMID: 22144693 3. Xu, W. et al. (2016) The Journal of biological chemistry 291, 4282-93. PMID: 26733203 4. Wang, J. et al. (2018) The Journal of biological chemistry 293, 19330-19343. PMID: 30361435 5. Qian, K. et al. (2023) Nature 613, 160-168. PMID: 36477540 6. Toh, SY. et al. (2008) PloS one 3, e2890. PMID: 18682832 | ||||||||
| Примечание | For research use only. |
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