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| カタログ番号 | MY524147 |
|---|---|
| 種反応性 | Mouse |
| アプリケーション | ELISA, FCM |
| 宿主種 | Rat |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | SAA0412 |
| 抱合 | PerCP |
| ターゲット | Gamma-IP10, C-X-C motif chemokine 10, INP10, 10 kDa interferon gamma-induced protein, Small-inducible cytokine B10, SCYB10, IP-10, CXCL10 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PerCP |
| アクセッション番号 | P17515 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | C-X-C motif chemokine 10 (CXCL10/IP-10) is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. 1. Gao, N. et al. (2017) Angiogenesis 20, 505-518. PMID: 28623423 2. Lindell, DM. et al. (2008) European journal of immunology 38, 2168-79. PMID: 18624292 3. Wuest, TR. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 7985-93. PMID: 19017990 4. Srivastava, R. et al. (2017) Journal of virology 91. PMID: 28468883 5. Rappert, A. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8500-9. PMID: 15456824 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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