Anti-Mouse CXCL10/IP-10 Recombinant Antibody (SAA0412) (MY524107)

Name: Anti-Mouse CXCL10/IP-10 Recombinant Antibody (SAA0412)
Brand: abinScience
SKU: MY524107
Price: 196 USD
Availability: InStock

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Catalog No.	MY524107
Species reactivity	Mouse
Applications	ELISA, FCM
Host species	Rat
Isotype	IgG1, kappa
Clone ID	SAA0412
Clonality	Monoclonal
Target	Gamma-IP10, C-X-C motif chemokine 10, INP10, 10 kDa interferon gamma-induced protein, Small-inducible cytokine B10, SCYB10, IP-10, CXCL10
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P17515
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	C-X-C motif chemokine 10 (CXCL10/IP-10) is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. 1. Gao, N. et al. (2017) Angiogenesis 20, 505-518. PMID: 28623423 2. Lindell, DM. et al. (2008) European journal of immunology 38, 2168-79. PMID: 18624292 3. Wuest, TR. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 7985-93. PMID: 19017990 4. Srivastava, R. et al. (2017) Journal of virology 91. PMID: 28468883 5. Rappert, A. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8500-9. PMID: 15456824
Note	For research use only.

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Anti-Mouse CXCL10/IP-10 Recombinant Antibody (SAA0412).pdf

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Anti-Mouse CXCL10/IP-10 Recombinant Antibody (SAA0412) (MY524107)

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