Anti-Mouse CXCL10/IP-10 Polyclonal Antibody (MY524014)

Name: Anti-Mouse CXCL10/IP-10 Polyclonal Antibody
Brand: abinScience
SKU: MY524014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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Fiche technique
SDS

Aperçu

Numéro de catalogue

MY524014

Description

Anti-Mouse CXCL10/IP-10 Polyclonal Antibody (MY524014) is a rabbit polyclonal antibody detecting IP-10 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Mouse CXCL10/IP-10 (Ile22-Pro98).

Cible

C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, Gamma-IP10, IP-10, C7, Interferon-gamma induced protein CRG-2, Small-inducible cytokine B10, Cxcl10, Crg2, Ifi10, Inp10, Scyb10

Purification

Purified by antigen affinity column.

Numéro d'accès

P17515

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

C-X-C motif chemokine 10 (CXCL10/IP-10) is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site.

1. Gao, N. et al. (2017) Angiogenesis 20, 505-518. PMID: 28623423

2. Lindell, DM. et al. (2008) European journal of immunology 38, 2168-79. PMID: 18624292

3. Wuest, TR. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 7985-93. PMID: 19017990

4. Srivastava, R. et al. (2017) Journal of virology 91. PMID: 28468883

5. Rappert, A. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8500-9. PMID: 15456824

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Mouse CXCL10/IP-10 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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Kits d'Essai

Anti-Mouse CXCL10/IP-10 Polyclonal Antibody (MY524014)

Aperçu

Images

Reférences

Fiche technique

SDS