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| カタログ番号 | MW575014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse DSG3 Polyclonal Antibody (MW575014) is a rabbit polyclonal antibody detecting Dsg3 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse DSG3 (Asn151-Asp591). | ||||||||
| ターゲット | Desmoglein-3, 130 kDa pemphigus vulgaris antigen homolog, Dsg3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O35902 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Desmoglein-3 (DSG3) is a ~107 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes. Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle. Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells. May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3. 1. Koch, PJ. et al. (1997) The Journal of cell biology 137, 1091-102. PMID: 9166409 2. Koch, PJ. et al. (1998) Journal of cell science 111 ( Pt 17), 2529-37. PMID: 9701552 3. Rötzer, V. et al. (2016) The Journal of investigative dermatology 136, 301-10. PMID: 26763450 | ||||||||
| 注意事項 | For research use only. |
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