Anti-Mouse EGFR Recombinant Antibody (SAA2220), APC (MF004127)

Name: Anti-Mouse EGFR Recombinant Antibody (SAA2220), APC
Brand: abinScience
SKU: MF004127
Price: 290 USD
Availability: InStock

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Número de catálogo	MF004127
Reactividad de especies	Mouse
Aplicaciones	ELISA, FCM, WB
Especie huésped	Rabbit
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	SAA2220
Conjugación	APC
Objetivo	EC:2.7.10.1, EGFR, ERBB, ERBB1, Epidermal growth factor receptor, HER1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Productos asociados	Rabbit IgG Recombinant Isotype Control Antibody (HyHEL-10), APC
Purificación	Affinity chromatography.
Número de acceso	Q01279
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Epidermal growth factor receptor (EGFR/ERBB1) is a ~134 kDa protein. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. EGFR is the therapeutic target of cetuximab (Erbitux) and panitumumab (Vectibix). 1. Fazioli, F. et al. (1993) The EMBO journal 12, 3799-808. PMID: 8404850 2. Peng, SC. et al. (2010) Nucleic acids research 38, 7446-57. PMID: 20639532 3. Eagles, DA. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119. PMID: 35131940
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse EGFR Recombinant Antibody (SAA2220), APC.pdf

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