Anti-Mouse EGFR Recombinant Antibody (SAA2220) (MF004107)

Name: Anti-Mouse EGFR Recombinant Antibody (SAA2220)
Brand: abinScience
SKU: MF004107
Price: 191 USD
Availability: InStock

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Aperçu

Numéro de catalogue	MF004107
Reactivité des espèces	Mouse
Applications	ELISA, FCM, IHC, WB
Espèce hôte	Rabbit
Clonalité	Monoclonal
Isotype	IgG
ID de clone	SAA2220
Cible	EC:2.7.10.1, EGFR, ERBB, ERBB1, Epidermal growth factor receptor, HER1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q01279
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Epidermal growth factor receptor (EGFR/ERBB1) is a ~134 kDa protein. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. EGFR is the therapeutic target of cetuximab (Erbitux) and panitumumab (Vectibix). 1. Fazioli, F. et al. (1993) The EMBO journal 12, 3799-808. PMID: 8404850 2. Peng, SC. et al. (2010) Nucleic acids research 38, 7446-57. PMID: 20639532 3. Eagles, DA. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119. PMID: 35131940
Note	For research use only.

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SDS-PAGE for Anti-Mouse EGFR/ERBB1 Antibody (SAA2220)

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Anti-Mouse EGFR Recombinant Antibody (SAA2220).pdf

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