Anti-Mouse EGFR Recombinant Antibody (SAA2220), PerCp (MF004147)

Name: Anti-Mouse EGFR Recombinant Antibody (SAA2220), PerCp
Brand: abinScience
SKU: MF004147
Price: 268 USD
Availability: InStock

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Каталожный номер	MF004147
Реактивность видов	Mouse
Применения	ELISA, FCM, WB
Хозяинский вид	Rabbit
Клоональность	Monoclonal
Изотип	IgG
ID клона	SAA2220
Конъюгация	PerCp
Цель	EC:2.7.10.1, EGFR, ERBB, ERBB1, Epidermal growth factor receptor, HER1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Связанные продукты	Rabbit IgG Recombinant Isotype Control Antibody (HyHEL-10), PerCP
Очистка	Affinity chromatography.
Номер доступа	Q01279
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Epidermal growth factor receptor (EGFR/ERBB1) is a ~134 kDa protein. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. EGFR is the therapeutic target of cetuximab (Erbitux) and panitumumab (Vectibix). 1. Fazioli, F. et al. (1993) The EMBO journal 12, 3799-808. PMID: 8404850 2. Peng, SC. et al. (2010) Nucleic acids research 38, 7446-57. PMID: 20639532 3. Eagles, DA. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119. PMID: 35131940
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse EGFR Recombinant Antibody (SAA2220), PerCp.pdf

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