Anti-Mouse FoxP3 Monoclonal Antibody (1A724 ), PE (MV388127)

Name: Anti-Mouse FoxP3 Monoclonal Antibody (1A724 ), PE
Brand: abinScience
SKU: MV388127
Price: 290 USD
Availability: InStock

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Número de catálogo	MV388127
Descripción	Anti-Mouse FOXP3 Monoclonal Antibody (1A724 ), PE [1A724] (MV388127) is a mouse monoclonal antibody detecting Foxp3 in FCM. Suitable for Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Reactividad de especies	Mouse
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	1A724
Objetivo	Forkhead box protein P3, Forkhead box protein P3 41 kDa form, Forkhead box protein P3, C-terminally processed, Foxp3, Scurfin
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q99JB6
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. _x005F_x005F_x000D_ _x005F_x005F_x000D_ 1. Song, X. et al. (2012) Cell reports 1, 665-75. PMID: 22813742 _x005F_x005F_x000D_ _x005F_x005F_x000D_ 2. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 _x005F_x005F_x000D_ _x005F_x005F_x000D_ 3. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 _x005F_x005F_x000D_ _x005F_x005F_x000D_ 4. Zhou, L. et al. (2008) Nature 453, 236-40. PMID: 18368049 _x005F_x005F_x000D_ _x005F_x005F_x000D_ 5. Pan, F. et al. (2009) Science (New York, N.Y.) 325, 1142-6. PMID: 19696312 _x005F_x005F_x000D_
Nota	For research use only.

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Anti-Mouse FoxP3 Monoclonal Antibody (1A724 ), PE.pdf

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