Anti-Mouse FoxP3 Polyclonal Antibody (MV388014)

Name: Anti-Mouse FoxP3 Polyclonal Antibody
Brand: abinScience
SKU: MV388014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

MV388014

Description

Anti-Mouse FOXP3 Polyclonal Antibody (MV388014) is a rabbit polyclonal antibody detecting FOXP3 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse FOXP3 (Ser189-Lys276).

Target

Forkhead box protein P3, IPEX, Scurfin, FOXP3

Purification

Purified by antigen affinity column.

Accession

Q99JB6

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2.

1. Song, X. et al. (2012) Cell reports 1, 665-75. PMID: 22813742

2. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681

3. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532

4. Zhou, L. et al. (2008) Nature 453, 236-40. PMID: 18368049

5. Pan, F. et al. (2009) Science (New York, N.Y.) 325, 1142-6. PMID: 19696312

Note

For research use only.

Images

References

Datasheet

Anti-Mouse FoxP3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse FoxP3 Polyclonal Antibody (MV388014)

Overview

Images

References

Datasheet

SDS

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