Anti-Mouse FoxP3 Monoclonal Antibody (1A724 ), PE (MV388127)

Name: Anti-Mouse FoxP3 Monoclonal Antibody (1A724 ), PE
Brand: abinScience
SKU: MV388127
Price: 290 USD
Availability: InStock

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Catalog No.	MV388127
Description	_x005F_x000D_ _x005F_x000D_ _x005F_x000D_ _x005F_x000D_ _x005F_x000D_ _x005F_x000D_ Anti-Mouse FOXP3 Monoclonal Antibody (1A724 ), PE [1A724] (MV388127) is a mouse monoclonal antibody detecting Foxp3 in FCM. Suitable for Mouse. _x005F_x000D_ _x005F_x000D_ _x005F_x000D_ Highlights _x005F_x000D_ _x005F_x000D_ _x005F_x000D_ ●Flow Cytometry — Validated for flow cytometry applications. _x005F_x000D_ _x005F_x000D_ _x005F_x000D_
Species reactivity	Mouse
Applications	FCM
Host species	Mouse
Isotype	IgG
Clone ID	1A724
Clonality	Monoclonal
Target	Forkhead box protein P3, Forkhead box protein P3 41 kDa form, Forkhead box protein P3, C-terminally processed, Foxp3, Scurfin
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q99JB6
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. _x005F_x000D_ _x005F_x000D_ 1. Song, X. et al. (2012) Cell reports 1, 665-75. PMID: 22813742 _x005F_x000D_ _x005F_x000D_ 2. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 _x005F_x000D_ _x005F_x000D_ 3. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 _x005F_x000D_ _x005F_x000D_ 4. Zhou, L. et al. (2008) Nature 453, 236-40. PMID: 18368049 _x005F_x000D_ _x005F_x000D_ 5. Pan, F. et al. (2009) Science (New York, N.Y.) 325, 1142-6. PMID: 19696312 _x005F_x000D_
Note	For research use only.

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Anti-Mouse FoxP3 Monoclonal Antibody (1A724 ), PE.pdf

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Anti-Mouse FoxP3 Monoclonal Antibody (1A724 ), PE (MV388127)

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