Anti-Mouse FoxP3 Monoclonal Antibody (1A724 ), PE (MV388127)

Name: Anti-Mouse FoxP3 Monoclonal Antibody (1A724 ), PE
Brand: abinScience
SKU: MV388127
Price: 290 USD
Availability: InStock

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Numéro de catalogue	MV388127
Description	Anti-Mouse FOXP3 Monoclonal Antibody (1A724 ), PE [1A724] (MV388127) is a mouse monoclonal antibody detecting Foxp3 in FCM. Suitable for Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Reactivité des espèces	Mouse
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG
ID de clone	1A724
Cible	Forkhead box protein P3, Forkhead box protein P3 41 kDa form, Forkhead box protein P3, C-terminally processed, Foxp3, Scurfin
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q99JB6
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. _x005F_x005F_x000D_ _x005F_x005F_x000D_ 1. Song, X. et al. (2012) Cell reports 1, 665-75. PMID: 22813742 _x005F_x005F_x000D_ _x005F_x005F_x000D_ 2. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 _x005F_x005F_x000D_ _x005F_x005F_x000D_ 3. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 _x005F_x005F_x000D_ _x005F_x005F_x000D_ 4. Zhou, L. et al. (2008) Nature 453, 236-40. PMID: 18368049 _x005F_x005F_x000D_ _x005F_x005F_x000D_ 5. Pan, F. et al. (2009) Science (New York, N.Y.) 325, 1142-6. PMID: 19696312 _x005F_x005F_x000D_
Note	For research use only.

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