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| カタログ番号 | MV388127 |
|---|---|
| 説明 |
Anti-Mouse FOXP3 Monoclonal Antibody (1A724 ), PE [1A724] (MV388127) is a mouse monoclonal antibody detecting Foxp3 in FCM. Suitable for Mouse.
Highlights
|
| 種反応性 | Mouse |
| アプリケーション | FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | 1A724 |
| ターゲット | Forkhead box protein P3, Forkhead box protein P3 41 kDa form, Forkhead box protein P3, C-terminally processed, Foxp3, Scurfin |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q99JB6 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. _x005F_x005F_x000D_ _x005F_x005F_x000D_1. Song, X. et al. (2012) Cell reports 1, 665-75. PMID: 22813742 _x005F_x005F_x000D_
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2. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 _x005F_x005F_x000D_
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3. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 _x005F_x005F_x000D_
_x005F_x005F_x000D_
4. Zhou, L. et al. (2008) Nature 453, 236-40. PMID: 18368049 _x005F_x005F_x000D_
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5. Pan, F. et al. (2009) Science (New York, N.Y.) 325, 1142-6. PMID: 19696312 _x005F_x005F_x000D_ |
| 注意事項 | For research use only. |
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