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Anti-Mouse FoxP3 Polyclonal Antibody (MV388014)

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Vista general
Número de catálogoMV388014
Descripción
Anti-Mouse FOXP3 Polyclonal Antibody (MV388014) is a rabbit polyclonal antibody detecting FOXP3 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Mouse FOXP3 (Ser189-Lys276).
Objetivo Forkhead box protein P3, IPEX, Scurfin, FOXP3
Purificación Purified by antigen affinity column.
Número de acceso Q99JB6
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2.

1. Song, X. et al. (2012) Cell reports 1, 665-75. PMID: 22813742
2. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681
3. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532
4. Zhou, L. et al. (2008) Nature 453, 236-40. PMID: 18368049
5. Pan, F. et al. (2009) Science (New York, N.Y.) 325, 1142-6. PMID: 19696312
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Mouse FoxP3 Polyclonal Antibody

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