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Anti-Mouse FoxP3 Polyclonal Antibody (MV388014)

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Aperçu
Numéro de catalogueMV388014
Description
Anti-Mouse FOXP3 Polyclonal Antibody (MV388014) is a rabbit polyclonal antibody detecting FOXP3 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Mouse FOXP3 (Ser189-Lys276).
Cible Forkhead box protein P3, IPEX, Scurfin, FOXP3
Purification Purified by antigen affinity column.
Numéro d'accès Q99JB6
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2.

1. Song, X. et al. (2012) Cell reports 1, 665-75. PMID: 22813742
2. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681
3. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532
4. Zhou, L. et al. (2008) Nature 453, 236-40. PMID: 18368049
5. Pan, F. et al. (2009) Science (New York, N.Y.) 325, 1142-6. PMID: 19696312
Note For research use only.
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Formula
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Anti-Mouse FoxP3 Polyclonal Antibody

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