Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), FITC (MB823117)

Name: Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), FITC
Brand: abinScience
SKU: MB823117
Price: 223 USD
Availability: InStock

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Каталожный номер	MB823117
Реактивность видов	Mouse
Применения	FCM
Хозяинский вид	Rat
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	MAR1-5A3
Конъюгация	FITC
Цель	Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), FITC
Номер доступа	P33896
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. 1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120 2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935 3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985 4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), FITC.pdf

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