Anti-Mouse IFNAR1 Recombinant Antibody (MAR1-5A3) (MB823107)

Name: Anti-Mouse IFNAR1 Recombinant Antibody (MAR1-5A3)
Brand: abinScience
SKU: MB823107
Price: 126 USD
Availability: InStock

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Overview

Catalog No.	MB823107
Species reactivity	Mouse
Applications	in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB
Host species	Rat
Isotype	IgG1, kappa
Clone ID	MAR1-5A3
Clonality	Monoclonal
Target	Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P33896
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. 1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120 2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935 3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985 4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679
Note	For research use only.

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Western blot

Western blot analysis was performed using anti-H4K5acK8ac monoclonal antibody at 1ug/mL on various samples.
Lane 1: 293T cell lysate
Lane 2: HCT116 cell lysate
Bioactivity

Detects recombinant mouse IFNAR1 (Catalog No: MB823012) in indirect ELISA

References

Datasheet

Anti-Mouse IFNAR1 Recombinant Antibody (MAR1-5A3).pdf

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Anti-Mouse IFNAR1 Recombinant Antibody (MAR1-5A3) (MB823107)

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