Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), PE (MB823127)

Name: Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), PE
Brand: abinScience
SKU: MB823127
Price: 290 USD
Availability: InStock

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Numéro de catalogue	MB823127
Reactivité des espèces	Mouse
Applications	FCM
Espèce hôte	Rat
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	MAR1-5A3
Conjugaison	PE
Cible	Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PE
Numéro d'accès	P33896
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. 1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120 2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935 3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985 4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), PE.pdf

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