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Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3), PerCP (MB823147)

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Vista general
Número de catálogoMB823147
Reactividad de especiesMouse
AplicacionesFCM
Especie huéspedRat
ClonalidadMonoclonal
IsotipoIgG1, kappa
ID de clonMAR1-5A3
ConjugaciónPerCP
Objetivo Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1
Nivel de endotoxinas Please contact with the lab for this information.
Productos asociados Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PerCP
Número de acceso P33896
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Estabilidad y almacenamiento Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo

Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120
2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935
3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985
4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679
Nota For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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